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Updated: Jul 22, 2025
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In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
Published on: January 9, 2020
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Genetically engineered mouse models of head and neck cancers
Jason Tasoulas1,2, Sonal Srivastava3, Xiaonan Xu4
1Department of Otolaryngology-Head and Neck Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Oncogene
|July 20, 2023
Summary
Genetically engineered mouse models (GEMMs) are crucial for studying head and neck cancers. This review details available GEMMs, aiding researchers in selecting appropriate models for specific investigations.
Area of Science:
- Oncology
- Genetics
- Translational Research
Background:
- Head and neck cancers affect millions globally, necessitating advanced research models.
- Genetically engineered mouse models (GEMMs) are vital for understanding cancer mechanisms and developing personalized therapies.
- While slower to develop than for other cancers, GEMMs now exist for head and neck cancers, capturing tumor heterogeneity and microenvironment.
Purpose of the Study:
- To provide a comprehensive overview of existing head and neck cancer GEMMs.
- To guide researchers in selecting the most suitable GEMMs for their specific research questions.
- To highlight the progress and utility of GEMMs in head and neck cancer research.
Main Methods:
- Systematic review of literature on head and neck cancer GEMMs.
- Categorization of GEMMs based on cancer type (squamous cell carcinoma, nasopharyngeal carcinoma, salivary, thyroid).
- Analysis of the recapitulation capabilities of different GEMMs regarding disease aspects and tumor microenvironment.
Main Results:
- Several GEMMs are now available that mimic key features of head and neck cancers.
- Each GEMM approach recapitulates specific aspects of the disease, requiring careful selection.
- Models cover diverse head and neck cancer subtypes, including squamous cell carcinoma, nasopharyngeal carcinoma, and glandular carcinomas.
Conclusions:
- GEMMs are indispensable tools for advancing head and neck cancer research.
- Appropriate selection of GEMMs is critical for successful and targeted research outcomes.
- The availability of diverse GEMMs facilitates a deeper understanding and improved therapeutic strategies for head and neck cancers.
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