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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Polymeric Microneedle Array Fabrication by Photolithography

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Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment.

Pan Li¹, Chun Hui Liu¹, Yan Yan Zhao¹

¹School of Pharmacy, Weifang Medical University, Weifang 261053, Shandong, P.R. China.

Biomacromolecules

|July 21, 2023

Summary

New microneedles combine chemotherapy and photothermal therapy to effectively treat melanoma. This targeted approach offers a promising, minimally invasive treatment option for drug-resistant skin cancer.

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Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Melanoma exhibits resistance to conventional treatments like chemotherapy and radiotherapy.
There is a critical need for targeted, low-toxicity, and minimally invasive therapeutic strategies.
Developing novel drug delivery systems is essential for improving melanoma treatment efficacy.

Purpose of the Study:

To design and fabricate novel microneedles (MNs) for enhanced melanoma targeting and synergistic therapy.
To investigate the combined efficacy of chemotherapy and photothermal therapy (PTT) using a single microneedle system.
To evaluate the in vivo therapeutic effects and safety of the developed microneedle system in a melanoma mouse model.

Main Methods:

Fabrication of DTIC/ICG-Fe3O4@TpBD BSP/HA microneedles incorporating magnetic nanoparticles, dacarbazine (DTIC), and indocyanine green (ICG).
Utilized magnetic targeting for enhanced accumulation of nanoparticles in tumor tissue.
Administered near-infrared (NIR) light irradiation to activate ICG for photothermal therapy and assessed drug release from the Bletilla polysaccharide (BSP)/hyaluronic acid (HA) matrix.
Evaluated therapeutic efficacy through in vivo studies on B16-OVA melanoma-bearing mice.

Main Results:

The DTIC/ICG-Fe3O4@TpBD BSP/HA microneedles demonstrated effective magnetic targeting to melanoma tissue.
Combined chemotherapy and PTT via microneedles synergistically inhibited melanoma tumor growth in vivo.
The treatment showed no signs of tumor recurrence and did not cause significant weight loss in the mice, indicating a favorable safety profile.

Conclusions:

DTIC/ICG-Fe3O4@TpBD BSP/HA microneedles offer a promising dual-action therapeutic approach for melanoma.
This innovative system effectively combines chemotherapy and photothermal therapy for enhanced anticancer effects.
The developed microneedle technology presents a novel and potentially clinically applicable strategy for melanoma treatment.