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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
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Do interventions for malignant pleural effusions impact on patient reported fatigue levels?
Donna Wakefield1, Avinash Aujayeb2
1Consultant in Palliative Medicine, North Tees and Hartlepool NHS Foundation Trust; Honorary Research Fellow, Population Health Sciences Institute, Newcastle University, UK.
International Journal of Palliative Nursing
|July 21, 2023
Summary
Interventions for malignant pleural effusions (MPEs) may improve patient fatigue. This pilot study found the methodology acceptable, though a larger trial is needed to confirm findings on MPE treatment.
Area of Science:
- Pulmonology
- Oncology
- Palliative Care
Background:
- Malignant pleural effusions (MPEs) are common and linked to poor prognosis and significant symptom burden.
- Previous research on MPEs has predominantly addressed breathlessness.
- Fatigue is a key symptom in MPE patients, yet less studied.
Purpose of the Study:
- To assess the impact of MPE interventions on patient fatigue levels.
- To evaluate the feasibility and acceptability of the study methodology for MPE research.
Main Methods:
- A prospective pilot study conducted at an adult pleural service.
- Utilized the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale to measure fatigue.
- Collected demographic and confounding data, assessing feasibility over 7 months.
Main Results:
- The study population had a mean age of 73, with lung cancer and mesothelioma being predominant diagnoses.
- Patient participation and the study methodology were deemed acceptable.
- An improvement in fatigue scores was observed in patients completing 30-day follow-up, despite a high attrition rate due to health deterioration.
Conclusions:
- The study protocol was acceptable, and MPE interventions showed potential for improving fatigue.
- The small sample size necessitates a larger, statistically powered study to influence clinical practice regarding MPE management and symptom control.
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