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Catalytic spike antibodies: A new paradigm in neutralization
1Ragon Institute of Mass General, MIT, and Harvard, 400 Technology Square, Cambridge, MA 02139, USA.
Cell Chemical Biology
|July 21, 2023
Abstract:
In this issue, McConnell et al.10 demonstrate that COVID-19 convalescent plasma (CCP)-derived antibodies can neutralize SARS-CoV-2 by proteolytically cleaving the spike protein. The CCP antibody-mediated catalysis has broader implications beyond COVID-19 and can be applicable in understanding the mechanism of antibody-based neutralization of different pathogens.

