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[Early prognosis of intracranial hemorrhage in premature infants]
Insights
Intracerebral hemorrhage in premature infants significantly impacts survival and development. Survivors often experience abnormal psychomotor development, highlighting the need for specialized neonatal care.
Area of Science:
- Neonatal Neurology
- Pediatric Neurodevelopment
- Perinatal Medicine
Context:
- Intracerebral hemorrhage (ICH) is a serious complication in premature infants.
- This study examines ICH occurrence, survival, and neurodevelopmental outcomes in a cohort of premature infants.
Purpose:
- To investigate the incidence, timing, and risk factors of ICH in premature infants.
- To assess the impact of ICH on survival rates and psychomotor development up to 19 months of age.
Summary:
- 87 premature infants (mean gestational age 29.5 weeks) developed ICH between 1979-1984.
- 46 infants died; survival was linked to gestational age and hemorrhage grade.
- 55% of survivors showed abnormal psychomotor development, compared to 13.5% in controls.
Impact:
- ICH is common in very premature infants (27-30 weeks gestation), often occurring within the first four days of life.
- Early complications like ventricular dilatation and hydrocephalus were more frequent in infants <31 weeks.
- Abnormal neurodevelopmental outcomes are significantly more prevalent in premature infants with ICH.
Abstract:
Between July 1979 and June 1984 an intracerebral haemorrhage developed in 87 premature infants (mean gestational age 29.5 weeks, mean birth weight 1156g). 46 of these died, 41 infants survived. Their psychomotoric development was followed up to a mean age of 19 months. In 63% of the patients the haemorrhage occurred during the first four days of life. Its frequency was highest in premature infants of 27 to 30 weeks of gestation. The survival rate was influenced by the gestational age and by the grade of haemorrhage. Early complications such as ventricular dilatation, hydrocephalus occlusus and porencephaly were seen especially in very immature infants (less than 31 weeks). The frequency of abnormal psychomotoric development in 55% of these infants contrasts with 13.5% in premature infants (less than 1 500 g) without intracerebral haemorrhage.