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Echocardiographic Assessment Of Left Ventricular Function After COVID-19 Vaccination In Adults

Hala Ahmed Mohamed Ahmed Wahdan1, Reda Biomy2, Wael Anwer Haseeb1

  • 1Department of Cardiology, Kafrelsheikh University,Egypt.

JPMA. the Journal of the Pakistan Medical Association
|July 24, 2023
PubMed

Insights

COVID-19 vaccines showed no significant impact on left ventricular function. Echocardiography assessments confirmed acceptable safety profiles for various vaccine types, including AstraZeneca, Pfizer-BioNTech, and Sinopharm.

Area of Science:

  • Cardiology
  • Vaccinology
  • Echocardiography

Background:

  • Left ventricular function is a key indicator of cardiac health.
  • Assessing the impact of coronavirus disease-2019 (COVID-19) vaccines on cardiac function is crucial for public health.
  • Echocardiography, including speckle tracking, is a primary tool for evaluating left ventricular performance.

Purpose of the Study:

  • To evaluate left ventricular function using conventional and speckle tracking echocardiography in individuals vaccinated against COVID-19.
  • To determine if COVID-19 vaccination affects global longitudinal strain (GLS).
  • To compare the cardiac safety profiles of different COVID-19 vaccine types.

Main Methods:

  • A cohort study involving 100 adult participants who received COVID-19 vaccines.
  • Echocardiography performed at baseline and two weeks post-vaccination to assess GLS.
  • Analysis included conventional echocardiography, speckle tracking, and statistical comparison of pre- and post-vaccination parameters.

Main Results:

  • No significant difference was observed in global longitudinal strain before and after COVID-19 vaccination (p<0.063).
  • The study included participants who received AstraZeneca, Pfizer-BioNTech, and Sinopharm vaccines.
  • No significant variation in GLS was found between different vaccine types (p=0.584).

Conclusions:

  • COVID-19 vaccines demonstrated acceptable safety profiles concerning left ventricular function.
  • The assessed vaccines (AstraZeneca, Pfizer-BioNTech, Sinopharm) did not adversely affect cardiac function.
  • Echocardiographic evaluation supports the cardiac safety of COVID-19 vaccination.
Abstract

Keywords:
COVID-19, Myocarditis, Echocardiography, Electrocardiography, Myocardial Infarction, Cardiology.

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