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Metabolite-sensing GPCRs controlling interactions between adipose tissue and inflammation.
Elaine M Duncan1, Luca Vita1, Bethany Dibnah1
1Centre for Translational Pharmacology, University of Glasgow, Glasgow, United Kingdom.
Frontiers in Endocrinology
|July 24, 2023
Summary
Metabolic disorders involve inflammation, with adipose tissue metabolites signaling through G protein-coupled receptors (GPCRs). Targeting these GPCRs offers potential treatments for obesity and diabetes.
Area of Science:
- Biochemistry
- Immunology
- Endocrinology
Background:
- Metabolic disorders like obesity and diabetes are linked to chronic inflammation in metabolic tissues.
- Adipose tissue releases metabolites that act as key signaling molecules influencing inflammation.
Purpose of the Study:
- To explore the role of G protein-coupled receptors (GPCRs) in mediating metabolic-immune interactions.
- To understand how specific metabolite-activated GPCRs contribute to metabolic disorders.
Main Methods:
- Investigated signaling pathways involving GPCRs activated by adipose tissue metabolites.
- Focused on free fatty acid receptor 4 (FFA4), hydroxy carboxylic acid receptors (HCAR2, HCAR3), and succinate receptors.
Main Results:
- Identified key GPCRs (FFA4, HCAR2, HCAR3, succinate receptor) activated by adipose metabolites.
- These GPCRs are expressed on adipocytes and macrophages, mediating metabolic-inflammatory crosstalk.
Conclusions:
- Understanding metabolite-GPCR interactions is crucial for metabolic disorder pathogenesis.
- Targeting these GPCRs presents a potential therapeutic strategy for metabolic diseases.
Keywords:
G protein-coupled receptoradiposefree fatty acidhydroxy carboxylic acidsinflammationmetabolite signallingsuccinateMore Related Videos
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