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Maternal asthma in relation to infant size and body composition
Danielle R Stevens1,2, Edwina Yeung2, Stefanie N Hinkle2,3
1Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park.
The Journal of Allergy and Clinical Immunology. Global
|July 24, 2023
Summary
Maternal asthma during pregnancy did not impact infant size or body composition in a prospective study. This finding suggests pregnancy asthma does not significantly alter offspring development in terms of weight or fat mass.
Area of Science:
- Obstetrics and Gynecology
- Perinatal Health
- Pediatric Development
Background:
- Asthma affects approximately 10% of pregnancies.
- Maternal asthma may influence infant health via hypoxic and inflammatory pathways.
- Potential impacts include alterations in infant size and body composition.
Purpose of the Study:
- To investigate associations between maternal asthma and specific asthma phenotypes during pregnancy.
- To determine the relationship between maternal asthma and infant size and body composition at birth and during early infancy.
Main Methods:
- Prospective cohort study (B-WELL-Mom, 2015-19) of 418 pregnant individuals.
- Classified maternal asthma and phenotypes (atopy, onset, control, severity, etc.).
- Assessed infant outcomes: weight, length, head circumference, skinfolds, and body composition (fat/lean mass) via air displacement plethysmography.
Main Results:
- Infants of mothers with asthma showed no significant differences in fat mass, birth weight, or postnatal weight compared to infants of non-asthmatic mothers.
- Few associations were found between maternal asthma or its phenotypes and infant size or body composition.
- Mean infant fat mass was 11.0 ± 4.2% in the asthma group.
Conclusions:
- Maternal asthma during pregnancy was not associated with differences in infant size or body composition in this cohort.
- Findings suggest pregnancy asthma does not significantly alter key infant growth parameters.
- Further research may explore subtle effects or specific asthma phenotypes.
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