Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

27
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
27
Glaucoma: Overview01:25

Glaucoma: Overview

623
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
623
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

10
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
10

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Turnover Intentions Among Intensive Care Healthcare Workers: Key Factors Influencing Decisions to Stay or Leave.

Acta anaesthesiologica Scandinavica·2026
Same author

Incidence, clinical characteristics and outcome of spontaneous cerebellar intracerebral haemorrhage in a Norwegian population.

European stroke journal·2026
Same author

Joint trajectories of brain atrophy, white matter hyperintensities and cognition quantify brain maintenance.

Nature communications·2026
Same author

Spectrum of double heterozygosity in individuals diagnosed with hereditary breast and ovarian cancer.

European journal of cancer (Oxford, England : 1990)·2026
Same author

Diagnostic performance of prehospital large-vessel occlusion detection scales in patients with suspected acute stroke: a retrospective validation study. The Akershus Study of Ischemic Stroke and Thrombolysis.

European stroke journal·2026
Same author

Machine Diagnostics and Machine Phenotyping of Migraine: A HUNT Study.

Neurology·2026

Related Experiment Video

Updated: Jul 22, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

6.6K

Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as

Bendik S Winsvold1,2,3,4, Aster V E Harder5,6, Caroline Ran7

  • 1Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.

Annals of Neurology
|July 24, 2023
PubMed
Summary
This summary is machine-generated.

This study identified genetic risk variants for cluster headache, revealing a genetic link to smoking as a causal factor. It provides biological insights into this neurological condition.

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

3.8K

Related Experiment Videos

Last Updated: Jul 22, 2025

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
06:07

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

6.6K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.3K
Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

3.8K

Area of Science:

  • Genetics
  • Neurology
  • Epidemiology

Background:

  • Cluster headache is a debilitating neurological disorder with a significant genetic component.
  • Understanding the genetic architecture of cluster headache is crucial for developing targeted therapies.

Approach:

  • Conducted the first genome-wide association study (GWAS) meta-analysis for cluster headache, integrating data from European and East Asian cohorts.
  • Utilized advanced methods including expression quantitative trait loci (eQTLs), transcriptome-wide association studies (TWAS), and fine-mapping to prioritize candidate causal genes.
  • Performed downstream analyses such as gene set enrichment, genetic correlation, and Mendelian randomization to explore biological pathways and causal relationships.

Key Points:

  • Identified 9 independent genetic signals in 7 loci from the primary meta-analysis and one additional locus in the trans-ethnic analysis.
  • Prioritized 20 potentially causal genes, showing enrichment in artery and brain tissues.
  • Established genetic correlations with smoking, risk-taking behavior, ADHD, depression, and musculoskeletal pain.
  • Mendelian randomization indicated that smoking intensity causally affects cluster headache risk.

Conclusions:

  • This GWAS meta-analysis provides novel insights into the genetic basis of cluster headache.
  • Identified smoking as a significant causal risk factor for cluster headache.
  • The findings pave the way for future research into the biological mechanisms and potential treatments for cluster headache.