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The Crosstalk between Nephropathy and Coagulation Disorder: Pathogenesis, Treatment, and Dilemmas

Zhiwei Qiu1,2, Xiaocong Pang1,2, Qian Xiang1,2

  • 1Department of Pharmacy , Peking University First Hospital, Beijing , China.

Journal of the American Society of Nephrology : JASN
|July 24, 2023
PubMed

Insights

Kidney disease and blood clotting significantly influence each other, posing risks like thrombosis and bleeding in patients. Further research is needed to understand kidney effects on coagulation and develop targeted therapies for nephropathy.

Area of Science:

  • Nephrology and Hematology
  • Investigating the intricate relationship between renal function and hemostasis.

Background:

  • Kidney diseases, including nephrotic syndrome, chronic kidney disease (CKD), and end-stage kidney disease (ESKD), are associated with significant risks of thrombosis and bleeding.
  • Current anticoagulant and procoagulant therapies can lead to adverse effects like anticoagulation-related nephropathy and heparin-induced thrombocytopenia, complicating patient prognosis.

Approach:

  • Systematic review of existing research on the bidirectional interaction between the coagulation system and kidney diseases.
  • Analysis of the current understanding of how the kidney influences coagulation, highlighting areas needing further investigation.
  • Evaluation of clinical treatments for coagulation disorders in nephropathy and vice versa.

Key Points:

  • The kidney's extensive vasculature makes it susceptible to coagulation disturbances, impacting overall kidney health.
  • While some therapeutic targets show promise, their efficacy in nephropathy requires more extensive study.
  • Understanding the kidney's role in coagulation is crucial for managing complications in kidney disease patients.

Conclusions:

  • The interplay between kidney disease and coagulation is complex, presenting significant clinical challenges.
  • Further research into the kidney's effects on coagulation is essential for developing effective therapeutic strategies.
  • This review provides insights for future research and clinical guidance in managing coagulation disorders in nephropathy.

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