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Risk of Chronic Kidney Disease in Hospitalized Patients with Hidradenitis Suppurativa

Nouf Almuhanna1,2,3, Sheldon W Tobe4,5, Raed Alhusayen1,2

  • 1Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Dermatology (Basel, Switzerland)
|July 24, 2023
PubMed

Insights

Hidradenitis suppurativa (HS) patients have a higher prevalence of chronic kidney disease (CKD). Early assessment for CKD in HS patients is recommended to prevent disease progression.

Area of Science:

  • Dermatology
  • Nephrology
  • Epidemiology

Background:

  • Hidradenitis suppurativa (HS) is linked to comorbidities like diabetes and cardiovascular disease, which are risk factors for chronic kidney disease (CKD).
  • The relationship between HS and CKD risk remains understudied.

Purpose of the Study:

  • To investigate the prevalence of chronic kidney disease (CKD) in patients diagnosed with hidradenitis suppurativa (HS).

Main Methods:

  • A cross-sectional, population-based study utilized data from the US National Inpatient Sample database.
  • The study period spanned from January 1, 2002, to December 31, 2012.
  • HS patients were compared to age- and gender-matched controls without HS.

Main Results:

  • The prevalence of CKD was higher in HS patients (6.3%) compared to controls (4.3%).
  • The association between HS and CKD was more pronounced in older patients (≥60 years), males, obese individuals, and those with diabetes, hyperlipidemia, or cardiovascular disease.
  • The adjusted odds ratio for CKD in HS patients was 1.1 (95% CI: 1.014-1.176) compared to non-HS patients.

Conclusions:

  • A potential association exists between hidradenitis suppurativa (HS) and chronic kidney disease (CKD).
  • Prompt evaluation by a nephrologist for any signs of CKD in HS patients is advised for early diagnosis and management.
  • Early detection may help mitigate the progression of CKD in individuals with HS.
Abstract

Keywords:
Acne inversaComorbidityHidradenitis suppurativaKidney diseaseRenal disease

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