Related Experiment Video For EML4-ALK gene fusion
Updated: Jul 22, 2025
Detection of Lung Tumor Progression in Mice by Ultrasound Imaging
Published on: February 27, 2020
Radiological evidence of rapid growth acceleration of a small part solid nodule found to be large-cell carcinoma of
Yunwei Lu1, Zewen Sun1, Hao Li1
1Department of Thoracic Surgery, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing, 100044, China.
Background:
With the widespread use of low-dose computed tomography for lung cancer screening, the detection rate of pulmonary lesions manifesting as ground-glass opacities (GGOs) has been increasing dramatically. The volume doubling time (VDT) has been introduced in clinical practice to monitor the potential growth rate of GGOs during long-term follow-up periods.
Case Presentation:
A 72-year-old never-smoker female diagnosed with mixed GGO manifested abruptly accelerated growth with sudden decreased VDT from 400 to 36 days. A thoracoscopic left lower lobectomy with mediastinal lymph node dissection was performed, and the diagnosis was stage IB large-cell neuroendocrine carcinoma (LCNEC). Next-generation sequencing of the tumor highlights an EML4-ALK gene fusion.
Conclusions:
The LCNEC may present as GGO with longer VDT in the early stage. VDT should calculate by the whole size either on the entire tumor diameter or on consolidation diameter. It is recommended that meticulous long-term follow-up with dynamic VDT monitoring may help select high-risk GGOs performing timely semi-elective surgical resection in clinical practice.
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