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The Emerging Role of Senotherapy in Cancer: A Comprehensive Review

Sarubala Malayaperumal1, Francesco Marotta2, Makalakshmi Murali Kumar1

  • 1Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai 603103, India.

Clinics and Practice
|July 25, 2023
PubMed

Insights

Senotherapy targets senescent cells to combat cancer by modulating the tumor microenvironment. This approach, using senolytic drugs, shows promise in combination with traditional cancer treatments.

Area of Science:

  • Oncology
  • Cellular Biology
  • Immunology

Background:

  • Senotherapy targets senescent cells, which contribute to tissue dysfunction and disease.
  • Senescent cells, through the senescence-associated secretory phenotype (SASP), influence the tumor microenvironment.
  • SASP can promote inflammation, immune evasion, and tumor cell proliferation.

Purpose of the Study:

  • To review the role of senescent cells and SASP in cancer.
  • To explore senotherapy as a novel cancer treatment strategy.
  • To discuss the combination of senotherapy with conventional cancer therapies.

Main Methods:

  • Literature review of senotherapy and its role in cancer.
  • Analysis of the interplay between senescent cells, SASP, and the tumor microenvironment.
  • Examination of emerging evidence on combination therapies.

Main Results:

  • Senescent cells and SASP play a complex role in cancer progression.
  • Senotherapy demonstrates potential for cancer treatment by targeting senescent cells.
  • Combination of senotherapy with chemotherapy and immunotherapy is an emerging area.

Conclusions:

  • Senotherapy offers a novel therapeutic strategy for cancer.
  • Targeting senescent cells can disrupt tumor-promoting mechanisms.
  • Further research into senotherapy combinations is warranted for improved cancer outcomes.
Keywords:
SASPcancercellular senescencesenolytessenolytic drugs

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