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Updated: Jul 21, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Copper-Catalyzed Aromatic Trifluoromethylation and the Related Transformations

Hideki Amii1

  • 1Division of Molecular Science, Graduate School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma, 376-8515, Japan.

Chemical Record (New York, N.Y.)
|July 25, 2023
PubMed
Summary

Trifluoromethylated aromatic compounds are vital in pharmaceuticals and agrochemicals. This work highlights efficient copper-mediated methods for introducing the trifluoromethyl group into aromatic compounds.

Keywords:
coppercross-couplingdifluoromethylfluorinetrifluoromethyl

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