Related Experiment Video
Updated: Jul 21, 2025
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Ten-year follow-up report and neurologic sequelae in a case of neonatal severe primary hyperparathyroidism
Nahid Khosroshahi1, Zahra Haghshenas2, Arya Afrooghe3
1Department of Pediatric Neurology, Bahrami Children's Hospital Tehran University of Medical Sciences Tehran Iran.
Insights
This study details a 10-year management of neonatal severe primary hyperparathyroidism (NSHPT) in Iran. Long-term outcomes include microcephaly, intellectual disability, and epilepsy, potentially linked to hypoxic-ischemic events.
Area of Science:
- Pediatric Endocrinology
- Neonatal Medicine
- Neurology
Background:
- Neonatal severe primary hyperparathyroidism (NSHPT) is a rare, life-threatening condition.
- Early diagnosis and management are crucial for long-term patient outcomes.
- This report documents the first NSHPT case managed in Iran.
Observation:
- A 10-year follow-up of a patient with NSHPT is presented.
- Clinical manifestations included microcephaly, mental retardation, and epilepsy.
- Brain MRI revealed findings consistent with a past hypoxic-ischemic event.
Findings:
- Effective long-term management strategies for NSHPT were employed.
- The study highlights potential neurological sequelae of NSHPT.
- Correlation between NSHPT and hypoxic-ischemic brain injury is suggested.
Implications:
- This case provides valuable insights into the long-term prognosis of NSHPT.
- It underscores the importance of multidisciplinary care for affected neonates.
- Findings contribute to understanding the neurological impact of severe hyperparathyroidism in infancy.
Abstract:
We present a 10-year follow-up and describe our experience in managing a case of neonatal severe primary hyperparathyroidism (NSHPT) for the first time in Iran. Microcephaly, mental retardation, and epilepsy may be long time sequels of NSHPT. The brain MRI findings are compatible with an old hypoxic-ischemic event.
