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Verapamil does not antagonize LSD-induced stimulus control.

J C Winter

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1986
    PubMed
    Summary
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    Pizotyline, but not verapamil, antagonized lysergic acid diethylamide (LSD) effects in rats. Calcium channel blockade by pizotyline is not essential for its anti-LSD properties, suggesting alternative mechanisms of action.

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Behavioral Science

    Background:

    • Lysergic acid diethylamide (LSD) is a potent psychoactive substance.
    • Understanding the mechanisms of LSD's effects and potential antagonists is crucial for research.
    • Pizotyline and verapamil are drugs with known pharmacological actions.

    Purpose of the Study:

    • To investigate the antagonistic and agonistic effects of pizotyline and verapamil on LSD in a rat model.
    • To determine if calcium channel antagonism is involved in pizotyline's anti-LSD effects.

    Main Methods:

    • Rats (N=6) were trained on a two-lever choice task under a food reinforcement schedule.
    • Discriminative stimulus control was established using LSD and saline.
    • Subjects were administered pizotyline or verapamil alone and in combination with LSD.

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    Main Results:

    • Pizotyline antagonized LSD effects and showed modest LSD-appropriate agonistic activity (18%).
    • Verapamil did not block LSD effects but exhibited greater LSD-appropriate agonistic activity (35%) than pizotyline.
    • Neither drug fully substituted for LSD.

    Conclusions:

    • Pizotyline's antagonism of LSD is not solely dependent on calcium channel blockade.
    • Verapamil demonstrated significant agonistic effects but lacked antagonistic properties against LSD.
    • Further research is needed to elucidate the precise mechanisms underlying pizotyline's interaction with LSD.