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Updated: Jul 21, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Progression in the Relationship between Exosome Production and Atherosclerosis

Yi Yang1, Jinxi Luo1, Yunan Kang2

  • 1Clinical Medical School, Weifang Medical University, Weifang, Shandong, 261053, P.R. China.

Current Pharmaceutical Biotechnology
|July 26, 2023
PubMed

Insights

Exosomes, tiny vesicles carrying molecules, are increasingly linked to atherosclerosis (AS) progression. Understanding their role offers new avenues for AS prevention, diagnosis, and treatment.

Area of Science:

  • Cardiovascular Research
  • Cell Biology
  • Biochemistry

Background:

  • Atherosclerosis (AS) is a primary cause of cardiovascular disease, imposing significant burdens.
  • Exosomes are lipid bilayer microvesicles involved in intercellular communication, delivering bioactive molecules.
  • Recent research clarifies the correlation between exosomes and the pathogenesis of atherosclerosis.

Purpose of the Study:

  • To review the composition, biogenesis, and release mechanisms of exosomes.
  • To summarize current research on exosomes in atherosclerosis.
  • To explore exosome-derived molecules, such as miRNAs, in AS progression.

Main Methods:

  • Literature review focusing on exosome biogenesis, extraction, and roles in AS.
  • Analysis of exosome composition, including nucleic acids and proteins.
  • Synthesis of recent findings on exosome-miRNA interactions in atherosclerosis.

Main Results:

  • Exosomes are rich in nucleic acids and proteins, with exosomal miRNAs playing a key role in AS.
  • Exosomes influence cellular communication and the internal environment, impacting AS.
  • Current research highlights exosomes as potential biomarkers and therapeutic targets for AS.

Conclusions:

  • Exosomes represent a promising area for novel strategies in atherosclerosis prevention, diagnosis, and treatment.
  • Further investigation into exosome functions can yield new therapeutic targets for cardiovascular disease.
  • Understanding exosome mechanisms provides insights into cellular communication in disease states.

Keywords:
Atherosclerosisbiogenesiscardiovascular diseaseexosomeextracellular vesiclesisolation technique.

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