Simulation of biochemical dynamics of and in fibroblast cell

Calcium dynamics is not only responsible for maintaining the framework and functions of the cell but also plays a role in the dynamics of other biochemical systems in the cell. Phospholipase C-$$ l ($$) has a crucial role in the function of fibroblast cells. Experiments have shown that $$ and $$ have interdependent dynamics in fibroblast cells. However, no reaction-diffusion model exists for the two-way feedback system dynamics of $$ and $$ in fibroblasts till date. The computational model is designed to investigate the impact of variations in several processes, such as the $$ pump, buffer process, source inflow, etc., on the system dynamics of $$ and $$ in fibroblast cells. The computational findings are obtained using finite element techniques, and the consequences of dysregulation in various processes on the spatiotemporal calcium and $$ dynamics in fibroblasts are investigated. The results lead to the conclusion that the effects of buffer, source influx, diffusion, and $$ pump can cause fluctuations in the dynamics of $$ and $$ in fibroblasts. Disruptions in these constitutive processes can result in changes in the dynamics of calcium and $$. Thus, the current model provides new/novel information regarding the precise dysregulatory constitutive systems that regulate calcium and $$ kinetics, such as source inflow, diffusion, $$, and buffer, can be responsible for excessive calcium and $$ concentrations leading to fibrotic illnesses such as cancer and fibrosis.