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Updated: Jul 21, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Left ventricular strain echocardiography in advanced uremic cardiomyopathy compared to dilated cardiomyopathy

Rizan Mohammadi1, Farnoosh Larti1, Roya Sattarzadeh Badkoubeh1

  • 1Department of Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran, 1419733141, Iran.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|July 26, 2023
PubMed

Insights

Advanced uremic cardiomyopathy (AUCM) patients exhibit significantly reduced global and segmental longitudinal strain compared to dilated cardiomyopathy (DCM). This cardiac dysfunction in AUCM highlights a key difference in myocardial function.

Area of Science:

  • Cardiology
  • Nephrology
  • Cardiac Imaging

Background:

  • Cardiac involvement is prevalent in end-stage renal disease (ESRD).
  • Advanced uremic cardiomyopathy (AUCM) represents a significant complication in ESRD patients.
  • Understanding myocardial strain patterns in AUCM is crucial for patient management.

Purpose of the Study:

  • To evaluate global and segmental longitudinal strain in AUCM patients.
  • To compare cardiac strain parameters between AUCM and dilated cardiomyopathy (DCM).
  • To identify distinct strain characteristics in AUCM.

Main Methods:

  • Utilized echocardiography to assess global and segmental longitudinal strain.
  • Compared strain values between patients with AUCM and DCM.
  • Analyzed strain patterns across different myocardial segments and base-to-apex gradients.

Main Results:

  • Mean global longitudinal strain (GLS) was significantly lower in AUCM patients (P=0.045).
  • AUCM showed reduced segmental strain in multiple regions, including inferoseptal, anterolateral, anteroseptal, and inferior segments, compared to DCM.
  • Both groups demonstrated an increase in segmental strain from base to apex.

Conclusions:

  • Segmental and global longitudinal strain are significantly diminished in AUCM relative to DCM.
  • The base-to-apex gradient of segmental strain is preserved in both AUCM and DCM.
  • These findings underscore the distinct myocardial impairment in AUCM.
Abstract

Keywords:
Dilated cardiomyopathyEnd stage renal diseaseGlobal longitudinal strainSegmental longitudinal strainSpeckle tracking echocardiography

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