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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

481
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
481
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

565
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
565
Glaucoma: Overview01:25

Glaucoma: Overview

623
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
623

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Related Experiment Video

Updated: Jul 21, 2025

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
09:03

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iPSCs-Based Therapy for Trabecular Meshwork.

Wei Zhu1,2, Xiaoyan Zhang3, Shen Wu4

  • 1Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, China. wzhu@qdu.edu.cn.

Handbook of Experimental Pharmacology
|July 26, 2023
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem cells (iPSCs) offer new ways to model trabecular meshwork (TM) in vitro and regenerate TM tissue for primary open-angle glaucoma (POAG) treatment.

Keywords:
GlaucomaInduced pluripotent stem cellsIntraocular pressureRegenerationTrabecular meshwork

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • The trabecular meshwork (TM) is crucial for aqueous humor outflow and intraocular pressure (IOP) homeostasis.
  • Dysfunctional TM cells or reduced TM cellularity are key factors in primary open-angle glaucoma (POAG).

Purpose of the Study:

  • To explore induced pluripotent stem cells (iPSCs) as a tool for modeling the TM in vitro.
  • To evaluate the potential of iPSCs for regenerating TM tissue in POAG.
  • To compare iPSC-derived TM models with conventional in vitro TM models.

Main Methods:

  • Summarizing current methods for differentiating TM-like cells from iPSCs.
  • Comparing iPSC-derived TM models against traditional in vitro TM models.
  • Discussing the efficacy of iPSC-derived TM cells in POAG models for TM regeneration.

Main Results:

  • iPSCs provide a viable method for creating in vitro TM models.
  • iPSC-derived TM cells show potential for TM regeneration in POAG.
  • iPSC technology is advancing glaucoma modeling and personalized treatment development.

Conclusions:

  • iPSCs are becoming indispensable tools for glaucoma research.
  • iPSC-based approaches facilitate the development of novel treatments for POAG.
  • The use of iPSCs holds promise for personalized regenerative therapies for the TM.