Related Experiment Video

Updated: Jul 21, 2025

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down
08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.3K

[Treatment Strategies for HER2-Positive Metastatic Colorectal Cancer]

Ayumu Yoshikawa1, Yoshiaki Nakamura

  • 1Dept. of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 27, 2023
PubMed

Insights

HER2-positive metastatic colorectal cancer is rare but treatable. Combination therapy with pertuzumab and trastuzumab is now approved in Japan for advanced cases, with new HER2-targeted drugs in development.

Area of Science:

  • Oncology
  • Gastroenterology

Context:

  • HER2-positive metastatic colorectal cancer (mCRC) represents a specific subtype of colorectal cancer, occurring in 2-4% of all cases.
  • This subtype is more prevalent in RAS wild-type mCRC (approx. 5%) compared to RAS mutant mCRC (0.2-1.4%).

Purpose:

  • To report on the TRIUMPH trial conducted in Japan evaluating HER2-targeted therapies for mCRC.
  • To highlight the regulatory approval of a combination therapy for HER2-positive unresectable advanced or recurrent colorectal cancer.

Summary:

  • The TRIUMPH trial in Japan investigated HER2-positive colorectal cancer.
  • Results led to the March 2022 approval of pertuzumab and trastuzumab combination therapy for HER2-positive unresectable advanced or recurrent colorectal cancer post-chemotherapy.

Impact:

  • This approval provides a new therapeutic option for a specific subset of colorectal cancer patients in Japan.
  • Ongoing research into novel HER2-targeted drugs, including antibody-drug conjugates and bispecific antibodies, promises future advancements in HER2-positive mCRC treatment.

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

13.8K
Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis04:22

Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis

Published on: March 3, 2023

472

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
110
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
558