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Prussian blue nanozymes: progress, challenges, and opportunities.

Hongliang He1, Mengmeng Long1, Yifan Duan1

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Prussian Blue Nanozymes (PBNZs) offer stable, reusable alternatives to natural enzymes for eliminating reactive oxygen species (ROS). These nanomaterials show great promise in biomedical applications, driving innovation in disease diagnosis and therapy.

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Area of Science:

  • Nanomaterials Science
  • Catalysis
  • Biomedical Engineering

Background:

  • Prussian Blue Nanozymes (PBNZs) mimic natural enzymes like catalase, peroxidase, and superoxide dismutase.
  • PBNZs overcome limitations of natural enzymes, offering enhanced stability, reusability, and lower costs.
  • Their unique properties have led to significant interest in disease diagnosis and therapy.

Purpose of the Study:

  • To provide a comprehensive review of Prussian Blue Nanozymes (PBNZs).
  • To explore PBNZ discovery, catalytic mechanisms, and strategies for modulating their enzyme-like activities.
  • To survey recent advancements in PBNZ applications for reactive oxygen species (ROS) scavenging in biomedicine.

Main Methods:

  • Systematic literature review of PBNZ research.
  • Analysis of PBNZ catalytic mechanisms and activity modulation strategies.
  • Survey of PBNZ applications in ROS scavenging for biomedical purposes.

Main Results:

  • PBNZs exhibit potent catalase, peroxidase, and superoxide dismutase activities.
  • PBNZs demonstrate superior stability, tunable activity, and reusability compared to natural enzymes.
  • Significant progress has been made in understanding PBNZ mechanisms and their application in ROS scavenging.

Conclusions:

  • PBNZs represent a promising class of nanomaterials for ROS elimination in biomedical fields.
  • Further research is needed to address challenges in translating PBNZs into clinical therapeutic agents.
  • PBNZs hold immense potential as innovative therapeutic agents in biomedicine.