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Related Experiment Video

Updated: Jul 21, 2025

Establishment of a Rat Model of Superior Sagittal-Sinus Occlusion via a Thread-Embolism Method
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Rhinosinusitis and Stroke: A Systematic Review.

Anna-Maria Papadopoulou1, Athanasia Marinou1

  • 1Department of Otolaryngology, Head and Neck Surgery, "G.Gennimatas" General Hospital of Athens, Athens, GRC.

Cureus
|July 27, 2023
PubMed
Summary
This summary is machine-generated.

Rhinosinusitis, a common inflammatory condition, is linked to a higher risk of stroke. This association between sinus inflammation and stroke incidence is statistically significant and independent of other risk factors.

Keywords:
acute rhinosinusitisatherosclerosischronic rhinosinusitiscomputed tomographyischemic strokemagnetic resonancerisk factorsinusitis complication

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Area of Science:

  • Medical Research
  • Inflammatory Diseases
  • Neurology

Background:

  • Rhinosinusitis is a prevalent inflammatory condition.
  • Intracranial vessel involvement in rhinosinusitis suggests a potential link to stroke.
  • Existing research indicates a possible association between sinus inflammation and cerebrovascular events.

Purpose of the Study:

  • To systematically review and evaluate the association between rhinosinusitis and cardiovascular diseases, with a specific focus on stroke.
  • To synthesize evidence from existing literature regarding the link between sinus inflammation and stroke risk.

Main Methods:

  • A comprehensive literature search was conducted on PubMed, covering studies from February 2000 to February 2022.
  • Search terms included 'rhinosinusitis', 'chronic rhinosinusitis', 'stroke', and 'ischemic stroke'.
  • The systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, including 14 eligible studies with over 1 million patients.

Main Results:

  • All included studies reported a statistically significant correlation between sinus inflammation (clinical or radiological) and an increased risk of stroke.
  • The observed association between rhinosinusitis and stroke risk was independent of traditional stroke risk factors.
  • The review encompassed data from 1,006,338 patients across 14 studies.

Conclusions:

  • Rhinosinusitis is significantly associated with an increased incidence of stroke.
  • Sinus inflammation represents an independent risk factor for stroke.
  • Further research may explore the mechanisms underlying this association.