Correlation Between Glycemic Variability and Diabetic Complications: A Narrative Review
Lining Huang1, Ying Pan1, Kaixin Zhou2
1Department of Endocrinology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Kunshan, 215300, People's Republic of China.
International Journal of General Medicine
|July 27, 2023
Summary
Diabetes mellitus disrupts glucose homeostasis, leading to complications. Reducing glycemic variability is a key target for improving diabetes management and preventing vascular damage.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Vascular Biology
Background:
- Diabetes mellitus is a metabolic disorder characterized by disturbed glucose homeostasis.
- High or low blood glucose levels can cause diabetic complications like neuropathy, nephropathy, retinopathy, and cardiovascular diseases.
- Glycemic variability, reflecting excessive glucose fluctuations, is an important indicator of impaired glucose homeostasis.
Purpose of the Study:
- To review research progress on quantifiable glycemic variability parameters.
- To explore the relationship between glycemic variability and vascular lesions.
- To investigate the underlying mechanisms linking glycemic variability to diabetic complications.
Main Methods:
- Literature review of current research on glycemic variability.
- Analysis of quantifiable glycemic variability parameters.
- Examination of studies correlating glycemic variability with vascular complications and their mechanisms.
Main Results:
- Glycemic variability is an emerging therapeutic target for diabetes management.
- Specific parameters of glycemic variability are linked to vascular lesions.
- Understanding these relationships can elucidate mechanisms of diabetic complications.
Conclusions:
- Limiting glycemic variability is crucial for improving diabetes metabolism.
- Glycemic variability parameters offer insights into predicting and preventing diabetic vascular complications.
- Further research into the mechanisms is needed to develop targeted therapies.
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