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Recent Advances in Research on Active Compounds Against Hepatic Fibrosis
Chuang Liu1, Siqi Li1, Changhao Zhang1
1Key Laboratory of Natural Resources of Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
Background:
Almost all chronic liver diseases cause fibrosis, which can lead to cirrhosis and eventually liver cancer. Liver fibrosis is now considered to be a reversible pathophysiological process and suppression of fibrosis is necessary to prevent liver cancer. At present, no specific drugs have been found that have hepatic anti-fibrotic activity.
Objective:
The research progress of anti-hepatic fibrosis compounds in recent ten years was reviewed to provide a reference for the design and development of anti-hepatic fibrosis drugs.
Methods:
According to the structure of the compounds, they are divided into monocyclic compounds, fused-heterocyclic compounds, and acyclic compounds.
Results:
In this article, the natural products and synthetic compounds with anti-fibrotic activity in recent ten years were reviewed, with emphasis on their pharmacological activity and structure-activity relationship (SAR).
Conclusion:
Most of these compounds are natural active products and their derivatives, and there are few researches on synthetic compounds and SAR studies on natural product.
Insights
Researchers reviewed anti-hepatic fibrosis compounds from the last decade, focusing on natural products. Few synthetic compounds and structure-activity relationship studies exist, highlighting a gap in developing new anti-fibrotic drugs.
Area of Science:
- Pharmacology
- Hepatology
- Medicinal Chemistry
Background:
- Chronic liver diseases frequently progress to fibrosis, cirrhosis, and liver cancer.
- Liver fibrosis is a reversible process crucial for preventing liver cancer.
- Currently, no specific drugs exhibit potent hepatic anti-fibrotic activity.
Purpose of the Study:
- To review research on anti-hepatic fibrosis compounds developed in the past ten years.
- To provide a reference for the design and development of novel anti-hepatic fibrosis drugs.
- To analyze pharmacological activity and structure-activity relationships (SAR) of these compounds.
Main Methods:
- Compounds were categorized based on their chemical structure: monocyclic, fused-heterocyclic, and acyclic.
- Literature review focused on natural products and synthetic compounds with anti-fibrotic activity.
- Emphasis was placed on pharmacological activity and SAR.
Main Results:
- The review identified numerous natural products and their derivatives with anti-fibrotic properties.
- A limited number of synthetic compounds with anti-fibrotic activity were reported.
- Structure-activity relationship (SAR) studies were predominantly focused on natural products.
Conclusions:
- Natural active products and their derivatives constitute the majority of reviewed compounds.
- There is a notable scarcity of research on synthetic anti-fibrotic compounds.
- Further SAR studies on natural products are needed for drug development.
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