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Updated: Jul 21, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Straightforward synthesis of chiral sulfonate-based ionic liquids from amino alcohols for chiral recognition
1Institute of Organic Chemistry, Clausthal University of Technology, Clausthal-Zellerfeld, Germany.
Abstract:
New sulfonate-based chiral salts were prepared from amino alcohols and sodium hydroxymethanesulfonate, vinyl sulfonate, or sultone. The synthesis started with different amino acids from the chiral pool and gave the desired products in just four steps. After cation metathesis, the salts were explored as chiral solvating agents (CSAs) in NMR studies. The new chiral ionic liquids (CILs) were successfully able to interact with different chiral guest molecules and formed diastereomeric aggregates. In some cases, baseline separation was observed. The influence of the structural differences in the CIL as well as the structural requirements of the guest molecule is discussed.
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