Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Automated leukocyte differentials in trisomy 13.

R A Bradley, J L Newsome, J S Krauss

    Southern Medical Journal
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Age-dependent benefits of developmental plasticity: Thermal acclimation benefits erode rapidly upon adult emergence.

    Journal of insect physiology·2026
    Same author

    Genetic variation in the shape of cold-survival curves in a single fly population suggests potential for selection from climate variability.

    Journal of evolutionary biology·2018
    Same author

    The Thermal Breadth of Nylanderia fulva (Hymenoptera: Formicidae) Is Narrower Than That of Solenopsis invicta at Three Thermal Ramping Rates: 1.0, 0.12, and 0.06°C min-1.

    Environmental entomology·2016
    Same author

    One phase of the dormancy developmental pathway is critical for the evolution of insect seasonality.

    Journal of evolutionary biology·2013
    Same author

    Aquatic respiration as a potential survival mechanism of Brephidium pseudofea (Lepidoptera: Lycaenidae) larvae to intertidal environments.

    Environmental entomology·2012
    Same author

    Polarization bistability and resultant spin rings in semiconductor microcavities.

    Physical review letters·2011
    Same journal

    The Five Essential Concepts of Developmental Medicine: A Medical Paradigm for People with Developmental Disabilities.

    Southern medical journal·2026
    Same journal

    α-Gal Syndrome in the South: Why We Need Treatment Trials, Not Just Tick Prevention.

    Southern medical journal·2026
    Same journal

    Association between Main Pancreatic Duct Size, Comorbidities, and Fistula Formation after Whipple Procedure for Pancreatic Cancer.

    Southern medical journal·2026
    Same journal

    Impact of Temperature Variation on Patients with Acute Severe Asthma.

    Southern medical journal·2026
    Same journal

    Assessing the Accuracy and Reliability of ChatGPT-4 to Answer Clinical EHR Messages in Sports Medicine.

    Southern medical journal·2026
    Same journal

    Diagnostic Utility and Clinical Implications of Inpatient Fecal Occult Blood Testing.

    Southern medical journal·2026
    See all related articles

    Physician review of blood smears is crucial for diagnosing genetic disorders like trisomy 13. Automated counters miss key cell features, highlighting the need for expert microscopic examination in suspected chromosomal abnormalities.

    Area of Science:

    • Genetics
    • Hematology
    • Cytogenetics

    Background:

    • Trisomy 13 is a severe genetic disorder.
    • Automated leukocyte differential counts may miss specific diagnostic cellular features.
    • Physician review of blood smears is essential for accurate diagnosis.

    Observation:

    • A case of a 4-month-old infant with trisomy 13 was reported.
    • Nuclear projections in polymorphonuclear leukocytes are characteristic of trisomy 13.
    • These nuclear projections were not detected by automated differential cell counts.

    Findings:

    • The presence of polymorphonuclear leukocyte nuclear projections was confirmed only after karyotyping results were available.
    • This case underscores the limitations of automated cell counting for certain genetic syndromes.

    Related Experiment Videos

  • Microscopic examination by a physician identified critical diagnostic markers.

    • Implications:

    • Reaffirms the diagnostic value of manual blood smear review in suspected cytogenetic diseases.
    • Highlights the importance of integrating microscopic and automated methods in hematological diagnostics.
    • Emphasizes the role of expert hematological review in identifying rare genetic conditions.