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Updated: Jul 21, 2025

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
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Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli

Published on: June 27, 2015

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PAI-1 regulates AT2-mediated re-alveolarization and ion permeability

Gibran Ali1, Mo Zhang1,2, Jianjun Chang1

  • 1Department of Cellular and Molecular Biology, Texas Lung Injury Institute, University of Texas at Tyler Health Science Center, Tyler, TX, USA.

Stem Cell Research & Therapy
|July 27, 2023
PubMed
Summary

Elevated plasminogen activator inhibitor-1 (PAI-1) in injured lungs impairs alveolar epithelial regeneration. This is due to reduced self-renewal of alveolar type 2 (AT2) cells, especially CD44+ cells, hindering lung repair.

Keywords:
DifferentiationOrganoidsProliferationRe-alveolarizationSerpine1

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