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Keratoconus International Consortium (KIC)- advancing keratoconus research.
Srujana Sahebjada1,2, Elsie Chan3,4,5, Gerard Sutton6,7
1Centre for Eye Research Australia, Level 7, 32 Gisborne St, East Melbourne, Victoria, 3002, Australia. Srujana.sahebjada@unimelb.edu.au.
BMC Ophthalmology
|July 27, 2023
Summary
The Keratoconus International Consortium (KIC) is a global study collecting data to better understand keratoconus. This research aims to identify factors influencing disease progression and treatment outcomes in keratoconus patients.
Area of Science:
- Ophthalmology
- Genetics
- Public Health
Background:
- Keratoconus is a progressive corneal disease causing vision loss due to thinning and bulging.
- Significant knowledge gaps exist regarding keratoconus etiology and progression.
- A collaborative, multi-center approach is essential for advancing understanding of this condition.
Purpose of the Study:
- To establish the Keratoconus International Consortium (KIC) for comprehensive keratoconus research.
- To address existing knowledge deficits through standardized data collection.
- To facilitate a deeper understanding of keratoconus across diverse populations.
Main Methods:
- Recruitment of keratoconus and control subjects globally.
- Utilizing a secure, online database for standardized data collection across international sites.
- Gathering data on demographics, medical history, clinical features, quality of life, economic impact, and genetic factors.
Main Results:
- 40 international clinics/hospitals have joined the KIC.
- Baseline data collected from 1130 keratoconus patients (median age 29.7 years, 61% male).
- 15.3% reported family history; 57.7% reported frequent eye rubbing.
Conclusions:
- The KIC's international, collaborative design and standardized data collection are key strengths.
- Analysis of cross-sectional and longitudinal data will elucidate factors influencing keratoconus progression.
- The consortium will significantly contribute to answering critical questions in keratoconus management and treatment.
