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Familial trigeminal neuralgia.

F M Braga, A de P Bonatelli, I Suriano

    Surgical Neurology
    |October 1, 1986
    PubMed
    Summary

    Familial trigeminal neuralgia, a rare condition, affected four siblings with pain onset between ages 24-31. Three underwent surgical treatment, highlighting the rarity of this genetic neurological disorder.

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    Area of Science:

    • Neurology
    • Genetics
    • Pain Medicine

    Background:

    • Trigeminal neuralgia (TN) is a chronic pain condition affecting the trigeminal nerve.
    • Familial occurrence of TN is exceptionally rare, with limited documented cases.
    • Understanding genetic predispositions is crucial for diagnosing and managing rare neurological disorders.

    Observation:

    • Presents four siblings (two males, two females) diagnosed with trigeminal neuralgia.
    • Pain onset in affected siblings ranged from 24 to 31 years old.
    • Three of the four siblings received surgical intervention for their condition.

    Findings:

    • The case series underscores the potential for familial clustering of trigeminal neuralgia.
    • The early onset of symptoms (24-31 years) in this family is noteworthy.
    • Surgical treatment was pursued in the majority of affected siblings.

    Implications:

    • Highlights the need for considering genetic factors in young-onset trigeminal neuralgia.
    • Suggests familial trigeminal neuralgia, though rare, warrants further investigation.
    • Contributes to the limited literature on hereditary patterns of trigeminal neuralgia.

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