Related Experiment Video
Updated: Jul 21, 2025
A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application
Published on: July 9, 2020
Antiplatelet Loading Effects Prior to Endovascular Treatment: Carotid Artery Stenosis versus Unruptured Cerebral
Kazumitsu Amari1, Eriko Sugawara2, Ryoo Yamamoto1,2
1Department of Neuroendovascular Therapy, Yokohama Brain and Spine Center, Yokohama, Kanagawa, Japan.
Insights
Dual antiplatelet therapy with aspirin and clopidogrel is effective for patients undergoing endovascular treatment for carotid artery stenosis and unruptured cerebral aneurysms. Platelet function and aggregation responses were similar across these conditions.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Pharmacology
Background:
- Carotid artery stenosis and cerebral aneurysms have distinct etiologies, potentially influencing platelet function and response to antiplatelet medications.
- Understanding these differences is crucial for optimizing peri-procedural antiplatelet therapy.
Purpose of the Study:
- To compare the antiplatelet loading effects of dual therapy (aspirin and clopidogrel) prior to endovascular treatment in patients with carotid artery stenosis versus unruptured cerebral aneurysms (UCA).
Main Methods:
- The study enrolled 9 patients with asymptomatic carotid artery stenosis (ACS), 14 with symptomatic carotid artery stenosis (SCS), and 20 with UCA.
- Antiplatelet loading effects were assessed using light transmission aggregometry and platelet aggregate detection.
Main Results:
- Despite differing risk factor prevalence, no significant differences were observed in maximum aggregation rates or platelet aggregation-prone properties among the three patient groups.
- This suggests a comparable response to dual antiplatelet therapy.
Conclusions:
- Preoperative dual antiplatelet therapy with aspirin and clopidogrel appears appropriate for patients with both carotid artery stenosis and cerebral aneurysms, regardless of underlying condition differences.
- This regimen may ensure adequate platelet inhibition for endovascular procedures in these patient populations.
Objective:
Carotid artery stenosis and cerebral aneurism may have different platelet functions and antiplatelet responses because these diseases have different etiologies. In this study, we compared the antiplatelet loading effects prior to endovascular treatment between carotid artery stenosis and unruptured cerebral aneurysm (UCA) patients.
Methods:
Nine patients with asymptomatic carotid artery stenosis (ACS), 14 with symptomatic carotid artery stenosis (SCS), and 20 with unruptured cerebral aneurysms were enrolled in this study. Antiplatelet (aspirin + clopidogrel) loading effects prior to endovascular treatment were evaluated using light transmission aggregometry and platelet aggregate detection methods.
Results:
Although there are differences in the prevalence of atherosclerosis risk factors, maximum aggregation rates in light transmission aggregometry and platelet aggregation-prone properties were not different in the three disease groups.
Conclusion:
Preoperative dual antiplatelet therapy with aspirin and clopidogrel may be appropriate for both carotid artery stenosis and cerebral aneurism patients even though their conditions and background factors differ.
More Related Videos
11:58Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
Published on: August 11, 2015
10:28Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Related Concept Videos
01:22Aneurysm IV: Nursing Management
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
01:26Aneurysm III: Interprofessional Care
01:27Peripheral Artery Disease III: Interprofessional Care