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Updated: Jul 21, 2025
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Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings
Published on: January 10, 2015
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The h-current controls cortical recurrent network activity through modulation of dendrosomatic communication
Yousheng Shu1, Andrea Hasenstaub2, David A McCormick3
1The Fudan University Fenglin Campus, 131 Dong'an Road, Xuhui District, Shanghai.
Biorxiv : the Preprint Server for Biology
|July 28, 2023
Summary
Reducing the h-current in cortical neurons enhances their ability to generate sustained activity. This finding suggests the h-current plays a key role in controlling neuronal network function and ensemble formation.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Cellular Electrophysiology
Background:
- The cerebral cortex relies on balanced excitation and inhibition for dynamic neuronal activity.
- Pyramidal neurons, particularly their dendrites, exhibit a prominent h-current.
Conclusions:
- Modulation of the h-current is a critical factor in controlling recurrent persistent activity in cortical networks.
- The h-current influences the formation and dissolution of neuronal ensembles by regulating network excitability.
- Targeting the h-current may offer novel strategies for modulating cortical network function.
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