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Reconstitution of Msp1 Extraction Activity with Fully Purified Components
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The AAA+ protein Msp1 recognizes substrates by a hydrophobic mismatch

Heidi L Fresenius1, Deepika Gaur1,2, Baylee Smith1,2

  • 1Previously at University of Toledo, Department of Chemistry & Biochemistry.

Biorxiv : the Preprint Server for Biology
|July 28, 2023
PubMed
Summary

Msp1 protein extracts misfolded membrane proteins by recognizing hydrophobic mismatches with the lipid bilayer. This extraction process is the rate-limiting step in Msp1

Keywords:
ATPase associated with diverse cellular activities (AAA)lipid bilayermembrane proteinmitochondriaproteostasis

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