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Hydrogel-Based Biosensors for Effective Therapeutics.

Mohzibudin Z Quazi1, Jimin Hwang1, Youngseo Song1

  • 1Department of Chemistry and the Natural Science Research Institute, Myongji University, 116 Myongji-ro, Yongin-si 17058, Gyeonggi-do, Republic of Korea.

Gels (Basel, Switzerland)
|July 28, 2023
PubMed
Summary
This summary is machine-generated.

This review explores advanced hydrogel-based biosensors engineered using synthetic and natural polymers. These innovative sensors show promise for multipurpose diagnostics and therapeutics, aiding in early disease detection.

Keywords:
DNA-based hydrogelsbiosensorsmRNA quantificationprogesterone detectionsensorsstimuli-responsive

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Area of Science:

  • Polymer Science and Engineering
  • Nanotechnology
  • Biotechnology

Background:

  • Polymer engineering and nanotechnology are advancing solutions for complex challenges.
  • Hydrogel-based sensors are crucial for early disease detection and therapeutic development.
  • Nano-therapeutics offer an alternative for treating challenging diseases.

Purpose of the Study:

  • To review recent advancements in synthetic and natural polymer-engineered hydrogel-based biosensors.
  • To explore their applications in multipurpose diagnostics and therapeutics.
  • To focus on DNA-based and DNA hydrogel-fabricated biosensors.

Main Methods:

  • Review of recent scientific literature on hydrogel-based biosensors.
  • Analysis of synthetic and natural polymer applications in biosensing.
  • Examination of DNA-based hydrogel biosensor designs and functionalities.

Main Results:

  • Hydrogels, as 3D polymeric networks, mimic tissue structures, enhancing their utility.
  • Engineered hydrogels enable the detection of various biomolecules and pathogenic proteins.
  • Recent studies highlight the potential of hydrogel biosensors in diagnostics and therapeutics.

Conclusions:

  • Hydrogel-based biosensors represent a significant development in nanoengineering for health applications.
  • These biosensors offer versatile platforms for both diagnostic and therapeutic purposes.
  • Further research into DNA-based hydrogel biosensors is warranted for advanced molecular diagnostics.