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Functional Hydrogels: A Promising Platform for Biomedical and Environmental Applications.

Mohzibudin Z Quazi1, Aaquib Saeed Quazi2, Youngseo Song1

  • 1Department of Chemistry and The Natural Science Research Institute, Myongji University, Myongji-ro, Yongin 17058, Gyeonggi-do, Republic of Korea.

International Journal of Molecular Sciences
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

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Functional hydrogels are engineered soft materials with diverse biomedical and environmental uses, including drug delivery and water purification. Despite their potential, challenges in biocompatibility and mechanical stability hinder widespread clinical application.

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Environmental Science

Background:

  • Functional hydrogels are advanced soft materials with 3D networks and high water content, designed for specific roles.
  • Their properties mimic the extracellular matrix, making them suitable for biomedical and environmental applications.
  • Stimuli-responsive hydrogels offer controlled drug delivery and targeted therapies.

Purpose of the Study:

  • To review rational hydrogel designs and synthesis techniques.
  • To analyze application-specific performance in biomedical and environmental fields.
  • To discuss hydrogel-based materials in clinical trials and remaining challenges.

Main Methods:

  • Literature review of functional hydrogel research.
  • Analysis of stimuli-responsive hydrogel mechanisms.
Keywords:
biomedical applicationscrosslinked polymer networkenvironmental applicationsfunctional hydrogelshealthcarestimuli responsive

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  • Examination of hydrogels in tissue engineering and environmental remediation.

    • Main Results:

    • Functional hydrogels show promise in drug delivery, tissue engineering, and water purification.
    • Stimuli-responsive designs enable precise control over therapeutic release.
    • Despite progress, clinical translation faces hurdles like biocompatibility and scalability.

    Conclusions:

    • Functional hydrogels offer versatile solutions for health and environmental issues.
    • Overcoming challenges in mechanical stability and biocompatibility is crucial for clinical success.
    • Future research should focus on unlocking hydrogel multifunctionality and responsiveness for broader applications.