Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Development of vignette-based evaluation with generative artificial intelligence (VEGA) for nursing students: a pilot study.

BMC medical education·2026

Same author

Diagnostic practices and variability in autoimmune gastritis: a national survey of gastrointestinal pathologists.

American journal of clinical pathology·2026

Same author

Recurrent and Bilateral Facial Palsy in Bell's Palsy and Ramsay-Hunt Syndrome: Risk Factors and Clinical Outcomes.

Plastic and reconstructive surgery·2026

Same author

Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression.

Cancer letters·2026

Same author

Over-the-Counter Emergency Contraception in Pharmacies across Dallas, Texas: A Secret Shopper Study.

Journal of pediatric and adolescent gynecology·2026

Same author

Reply: Interpreting outcomes in early liver transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026

Search research articles

Related Experiment Video

Updated: May 26, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Stimuli-Responsive DNA Hydrogel Design Strategies for Biomedical Applications.

Minhyuk Lee¹, Minjae Lee², Sungjee Kim¹

¹Department of Chemistry, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.

|June 25, 2025

Summary

This summary is machine-generated.

Stimuli-responsive DNA hydrogels offer advanced biocompatibility for smart biomedical applications. These versatile nanomaterials show promise in biosensing and targeted drug delivery systems.

Keywords:

bioanalysis biomedicines inorganic nanomaterial hybrid DNA hydrogels polymer hybrid DNA hydrogels pure DNA hydrogels stimuli responsiveness

More Related Videos

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Related Experiment Videos

Last Updated: May 26, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Area of Science:

Biomaterials Science
Nanotechnology
Polymer Chemistry

Background:

Hydrogels mimic biological tissues, offering biocompatibility and biodegradability.
DNA hydrogels possess unique properties like molecular recognition and low immunogenicity.
Stimuli-responsive DNA hydrogels are emerging as smart nanomaterials for biomedical uses.

Purpose of the Study:

To review recent advances in stimuli-responsive DNA hydrogel systems.
To explore hybridized DNA hydrogels and their response mechanisms.
To highlight biomedical applications in biosensing and drug delivery.

Main Methods:

Review of current literature on DNA hydrogel synthesis and applications.
Analysis of hybridization strategies with various nanomaterials (e.g., AuNPs, QDs) and polymers (e.g., pNIPAM).
Discussion of stimuli-responsive mechanisms triggered by microenvironments or molecules.

Main Results:

DNA hydrogels exhibit tunable properties through hybridization and stimuli-responsiveness.
Hybrid DNA hydrogels display diverse optical and chemical characteristics.
These systems show significant potential for advanced biosensing and controlled drug delivery.

Conclusions:

Stimuli-responsive DNA hydrogels are promising for next-generation biomedical technologies.
Further research is needed to address challenges and optimize performance.
Hybrid DNA hydrogels offer a versatile platform for sophisticated biosensing and drug delivery applications.