Bioactive milk peptides: an updated comprehensive overview and database

Area of Science:

• Food Science
• Biochemistry
• Nutritional Science

Background:

• Partial digestion of milk proteins generates bioactive peptides with various health benefits.
• The Milk Bioactive Peptide Database (MBPDB) was previously established by compiling existing literature.
• Ongoing research continues to uncover new functionalities and applications of these peptides.

Purpose of the Study:

• To provide a comprehensive update to the data within the MBPDB.
• To review the current research status of milk bioactive peptides across different functional categories.
• To stimulate future investigations into the bioactivities of milk peptides.

Main Methods:

• Literature review of existing research on milk bioactive peptides.
• Data compilation and update for the MBPDB.
• Categorization of peptide bioactivities based on scientific studies (in vitro, animal, clinical).

Main Results:

• The MBPDB has been updated with the latest data on milk bioactive peptides.
• A comprehensive review covers various activities: ACE-inhibitory, antimicrobial, antioxidant, DPP-IV inhibitory, opioid, anti-inflammatory, immunomodulatory, calcium absorption, bone health, and anticancer.
• Research spans from in vitro findings to animal and human clinical studies.

Conclusions:

• The updated MBPDB serves as a valuable resource for researchers.
• Milk bioactive peptides exhibit a wide range of scientifically validated health benefits.
• This review highlights the potential of milk peptides in functional foods and therapeutic applications.