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Peptide Identification Using Tandem Mass Spectrometry01:33

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Updated: Jul 21, 2025

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
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Bioactive milk peptides: an updated comprehensive overview and database.

Søren Drud-Heydary Nielsen1, Ningjian Liang2, Harith Rathish3

  • 1Department of Food Science, Aarhus University, Aarhus, Denmark.

Critical Reviews in Food Science and Nutrition
|July 28, 2023
PubMed
Summary
This summary is machine-generated.

This study updates the milk bioactive peptide database (MBPDB) with new research on peptides derived from milk proteins. It reviews their diverse health benefits, including antimicrobial and anticancer activities, for future research.

Keywords:
Peptidomicscaseinhydrolysatesin vitroin vivowhey

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Area of Science:

  • Food Science
  • Biochemistry
  • Nutritional Science

Background:

  • Partial digestion of milk proteins generates bioactive peptides with various health benefits.
  • The Milk Bioactive Peptide Database (MBPDB) was previously established by compiling existing literature.
  • Ongoing research continues to uncover new functionalities and applications of these peptides.

Purpose of the Study:

  • To provide a comprehensive update to the data within the MBPDB.
  • To review the current research status of milk bioactive peptides across different functional categories.
  • To stimulate future investigations into the bioactivities of milk peptides.

Main Methods:

  • Literature review of existing research on milk bioactive peptides.
  • Data compilation and update for the MBPDB.
  • Categorization of peptide bioactivities based on scientific studies (in vitro, animal, clinical).

Main Results:

  • The MBPDB has been updated with the latest data on milk bioactive peptides.
  • A comprehensive review covers various activities: ACE-inhibitory, antimicrobial, antioxidant, DPP-IV inhibitory, opioid, anti-inflammatory, immunomodulatory, calcium absorption, bone health, and anticancer.
  • Research spans from in vitro findings to animal and human clinical studies.

Conclusions:

  • The updated MBPDB serves as a valuable resource for researchers.
  • Milk bioactive peptides exhibit a wide range of scientifically validated health benefits.
  • This review highlights the potential of milk peptides in functional foods and therapeutic applications.