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Updated: Jun 27, 2026

Athymic Rat Model for Evaluation of Engineered Anterior Cruciate Ligament Grafts
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Management of Bone Loss and Tunnel Widening in Revision ACL Reconstruction
Christopher J McMellen1, Margaret A Sinkler1, Jacob G Calcei1,2
1Department of Orthopaedic Surgery, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Abstract:
➤ Both mechanical and biological factors can contribute to bone loss and tunnel widening following primary anterior cruciate ligament (ACL) reconstruction.➤ Revision ACL surgery success is dependent on graft position, fixation, and biological incorporation.➤ Both 1-stage and 2-stage revision ACL reconstructions can be successful in correctly indicated patients.➤ Potential future solutions may involve the incorporation of biological agents to enhance revision ACL surgery, including the use of bone marrow aspirate concentrate, platelet-rich plasma, and bone morphogenetic protein-2.
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