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Related Experiment Videos

Hereditary myopathy in Labrador retrievers: a morphologic study.

R E McKerrell, K G Braund

    Veterinary Pathology
    |July 1, 1986
    PubMed
    Summary
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    Hereditary myopathy in Labrador retrievers presents complex muscle and nerve changes. This study reveals muscle pathology with both neurogenic and myopathic features, though the cause remains unknown.

    Area of Science:

    • Veterinary Pathology
    • Canine Genetics
    • Neuromuscular Diseases

    Background:

    • Hereditary myopathies in dogs can affect skeletal muscle and peripheral nerves.
    • Understanding the specific pathological features is crucial for diagnosis and management.

    Purpose of the Study:

    • To characterize the histopathological and histochemical changes in skeletal muscle and peripheral nerves of Labrador retrievers with hereditary myopathy.
    • To investigate the potential neurogenic and myopathic components of the disease.

    Main Methods:

    • Histological and histochemical examination of biopsy and necropsy samples from affected dogs.
    • Analysis of skeletal muscle and peripheral nerve tissues.

    Main Results:

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  • Peripheral nerves showed normal findings.
  • Skeletal muscles exhibited diverse changes including fiber atrophy, angular fibers, fiber type grouping, internal nuclei, architectural disturbances, type II fiber deficiency, necrosis, regeneration, and fibrosis.
  • Observed muscle changes included features typically associated with neurogenic disorders and destructive myopathies.

    • Conclusions:

    • The hereditary myopathy in these Labrador retrievers displays a mixed pathology with both neurogenic and myopathic characteristics.
    • The underlying pathophysiology of this complex neuromuscular condition requires further investigation.