Related Experiment Video

Updated: Jul 21, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

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Research progress on post-translational modification of proteins and cardiovascular diseases

XueLi Cheng1,2, Kai Wang2, Yan Zhao2

  • 1Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital affiliated to Qingdao University, Jinan, 250014, Shandong, China.

Cell Death Discovery
|July 28, 2023
PubMed

Insights

Cardiovascular diseases (CVDs) are linked to epigenetic changes, specifically post-translational modifications (PTMs). Understanding these reversible protein alterations is key to developing new CVD treatments.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) pose significant global health risks.
  • Epigenetic modifications, including post-translational modifications (PTMs), are increasingly recognized in CVD pathogenesis.
  • PTMs like phosphorylation, acetylation, and newly discovered acylations are crucial for cardiovascular system function.

Purpose of the Study:

  • To review the mechanisms of common PTMs involved in cardiovascular disease.
  • To highlight the role of novel acylation modifications in CVD.

Main Methods:

  • Literature review of studies on PTMs and CVDs.
  • Focus on advancements in high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for PTM discovery.

Main Results:

  • Various PTMs, including phosphorylation, glycosylation, methylation, and acetylation, are implicated in CVDs.
  • Novel acylation modifications (propionylation, crotonylation, butyrylation, succinylation, lactylation, isonicotinylation) have been identified.
  • Protein conformational changes due to PTMs can alter function and contribute to CVDs.

Conclusions:

  • PTMs play a critical role in the development and progression of cardiovascular diseases.
  • The reversibility of PTMs offers potential therapeutic targets for CVDs.
  • Continued research into PTMs, especially novel acylations, is essential for understanding and treating CVDs.

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