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Stress Reduction Potential in Mice Ingesting DNA from Salmon Milt
Keiko Unno1, Kyoko Taguchi1, Mica Fujita2,3
1Tea Science Center, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
Biology
|July 29, 2023
Summary
Dietary DNA sodium salt (DNA-Na) supplementation reduced stress in mice. DNA-Na intake suppressed age-related hippocampal inflammation, suggesting a potential anti-stress effect of dietary DNA.
Area of Science:
- Nutrition Science
- Neuroscience
- Immunology
Background:
- Dietary nucleotides play a role in physiological functions, particularly during stress.
- Elucidating the specific benefits of dietary nucleotide supplementation remains challenging.
Purpose of the Study:
- To investigate the stress-relieving effects of DNA sodium salt (DNA-Na) derived from salmon milt.
- To explore the potential of DNA-Na in mitigating stress-induced inflammation, especially in aging contexts.
Main Methods:
- Utilized a territoriality-based stress load model in male mice to assess DNA-Na and yeast-derived RNA effects.
- Employed a chronic crowding stress model in aging mice (7 months old) compared to younger controls (2 months old).
- Analyzed gene expression related to hippocampal inflammation in response to DNA-Na supplementation under chronic stress.
Main Results:
- Mice fed a diet containing 1% DNA-Na showed reduced stress levels, while yeast-derived RNA had an insignificant effect.
- Older mice subjected to chronic crowding stress exhibited increased hippocampal inflammatory gene expression.
- DNA-Na supplementation suppressed the expression of these inflammatory genes in older, stressed mice.
Conclusions:
- Dietary DNA-Na demonstrates potential anti-stress properties.
- DNA-Na intake may help suppress age-related, stress-induced inflammation in the brain.
