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Updated: Jul 21, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Tumor Growth Ameliorates Cardiac Dysfunction

Lama Awwad1, Rona Shofti2, Tali Haas2

  • 1Department of Cell Biology and Cancer Science, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3525422, Israel.

Cells
|July 29, 2023
PubMed

Insights

Cancer progression surprisingly improves heart function during pressure overload. Tumors promote beneficial M1-to-M2 macrophage polarization in the heart, reducing cardiac hypertrophy and fibrosis, but this effect requires functional macrophages.

Area of Science:

  • Cardiovascular Biology
  • Oncology
  • Immunology

Background:

  • Heart failure and cancer are leading global causes of mortality.
  • Cardiac dysfunction is known to exacerbate cancer progression and metastasis.
  • The impact of tumor progression on cardiac remodeling remains largely unexplored.

Purpose of the Study:

  • To investigate the effects of tumor progression on cardiac remodeling under pressure overload.
  • To identify the mechanisms by which tumors influence cardiac adaptation to stress.

Main Methods:

  • Utilized a transverse aortic constriction (TAC) mouse model to induce pressure overload.
  • Introduced proliferating cancer cells (two different lines) into TAC-operated mice.
  • Performed integrative analysis including qRT-PCR, flow cytometry, and immunofluorescence.

Main Results:

  • Tumor-bearing mice exhibited reduced cardiac hypertrophy and fibrosis following TAC.
  • Cardiac contractile function was improved in tumor-bearing mice post-TAC.
  • Tumor-dependent M1-to-M2 macrophage polarization in the heart mediated these beneficial effects.
  • Macrophage depletion abolished the protective effects of tumors on cardiac function and fibrosis.

Conclusions:

  • Tumor progression can beneficially modulate cardiac remodeling in response to pressure overload.
  • Cardiac macrophage polarization is a key mechanism linking cancer and improved cardiac outcomes.
  • Targeting cardiac macrophages may offer novel therapeutic strategies for heart failure patients with cancer.
Keywords:
cardiac fibrosiscardiac hypertrophyheart failureimmune systemmacrophage polarizationtumor

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