Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases.

Area of Science:

• Gastroenterology
• Microbiology
• Physiology

Background:

• The intestinal barrier is crucial for nutrient absorption and preventing pathogen entry.
• Bile acids, synthesized from cholesterol, are modified by gut microbiota.
• Bile acids and gut microbiota interact with bile acid receptors (BARs) to maintain intestinal homeostasis.

Purpose of the Study:

• To review recent studies on bile acid disorder and intestinal barrier dysfunction.
• To elucidate the roles of bile acids, BARs, and gut microbiota in intestinal barrier dysfunction.
• To provide insights for future prevention and treatment strategies.

Main Methods:

• Literature review of recent studies.
• Synthesis of findings on bile acid metabolism and gut microbiota.
• Analysis of the interplay between bile acids, BARs, gut microbiota, and intestinal barrier function.

Main Results:

• Bile acid dysregulation is linked to intestinal barrier dysfunction.
• Bile acid receptors (BARs) and gut microbiota significantly influence barrier integrity.
• Specific alterations in bile acid profiles and microbial composition correlate with barrier defects.

Conclusions:

• Bile acids, BARs, and gut microbiota are key players in maintaining intestinal barrier function.
• Dysbiosis and altered bile acid metabolism contribute to barrier dysfunction and disease.
• Targeting bile acid pathways and the gut microbiota offers therapeutic potential for intestinal barrier disorders.