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Related Experiment Video

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Numerical Modeling and Simulation of Non-Invasive Acupuncture Therapy Utilizing Near-Infrared Light-Emitting Diode.

Sundeep Singh1, Andres Escobar2, Zexi Wang3

  • 1Faculty of Sustainable Design Engineering, University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada.

Bioengineering (Basel, Switzerland)
|July 29, 2023
PubMed
Summary

Near-infrared light-emitting diodes (LEDs) offer a non-invasive, acupuncture-like stimulus. This study models LED-skin interaction to optimize thermal dosage for safe and effective photothermal therapy.

Keywords:
acupointsacupuncturebio-heat transfercomputational modelinglight-tissue interactionphotothermal effectthermal therapy

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Area of Science:

  • Biomedical Engineering
  • Photomedicine
  • Computational Modeling

Background:

  • Acupuncture is a widely used complementary therapy.
  • Developing non-invasive alternatives to traditional acupuncture is of significant interest.
  • Understanding light-tissue interactions is crucial for photothermal therapies.

Purpose of the Study:

  • To investigate the use of near-infrared (NIR) light-emitting diodes (LEDs) for non-invasive, acupuncture-like physical stimulation.
  • To develop and validate a computational model for predicting light-tissue interaction and temperature distribution.
  • To identify optimal parameters for safe and effective LED-based photothermal therapy.

Main Methods:

  • Developed a 3D multi-layer skin tissue model for computational analysis.
  • Employed finite element analysis to solve Pennes' bioheat transfer equation coupled with the Beer-Lambert law.
  • Experimentally characterized LED irradiation profiles and validated the model using agar phantoms.

Main Results:

  • Simulated spatiotemporal temperature distribution within the skin tissue.
  • Investigated the effects of LED power, duration, distance, and multiple LEDs on temperature.
  • Identified safe operating power ranges for the selected LEDs.

Conclusions:

  • The developed computational model accurately predicts temperature distribution in skin tissue.
  • Optimizing thermal dosage through understanding critical factors enables safe and effective LED-based photothermal therapy.
  • NIR LEDs show promise as a non-invasive alternative for acupuncture-like stimulation.