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Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption
Olivier Escaffre1,2, Peter Szaniszlo3, Gabor Törő3
1Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Biomedicines
|July 29, 2023
Summary
Hydrogen sulfide (H2S) releasing compounds like GYY4137 show promise in protecting lung endothelial cells from COVID-19 damage. This study demonstrates H2S donor
Area of Science:
- Pulmonary Medicine
- Endothelial Biology
- COVID-19 Pathophysiology
Background:
- Lung microvascular endothelial injury is a key factor in COVID-19.
- Hydrogen sulfide (H2S) has demonstrated beneficial effects in various pathological conditions.
- Previous research suggests a therapeutic potential for H2S in COVID-19 treatment.
Purpose of the Study:
- To investigate the protective effect of the H2S donor GYY4137 on lung endothelial cell barrier function.
- To assess the impact of COVID-19 patient plasma and inactivated SARS-CoV-2 on endothelial barrier integrity.
- To correlate plasma cytokine/chemokine profiles, endothelial permeability, and disease severity.
Main Methods:
- Utilized an in vitro lung endothelial cell monolayer model.
- Challenged cells with COVID-19 patient plasma and inactivated SARS-CoV-2 virus.
- Measured real-time alterations in endothelial barrier permeability using electrical impedance.
Main Results:
- GYY4137 treatment significantly reduced endothelial barrier permeability when challenged with patient plasma.
- GYY4137 completely reversed endothelial barrier disruption induced by inactivated SARS-CoV-2.
- Disease severity correlated with plasma cytokine/chemokine profiles, but not with barrier permeability in this assay.
Conclusions:
- H2S-releasing compounds, such as GYY4137, can mitigate SARS-CoV-2-induced lung endothelial barrier disruption.
- These findings support the therapeutic potential of H2S donors for managing COVID-19 complications.
- Further research is warranted to explore H2S-based therapies for COVID-19.
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