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CASZ1: Current Implications in Cardiovascular Diseases and Cancers

Heng Jian1, Ansgar Poetsch1,2

  • 1Queen Mary School, Nanchang University, Nanchang 330006, China.

Biomedicines
|July 29, 2023
PubMed

Insights

Castor zinc finger 1 (CASZ1) protein plays roles in tissue differentiation and aldosterone antagonism. Aberrations in CASZ1 are linked to cardiovascular diseases and cancers, suggesting a complex "double-agent" role.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Castor zinc finger 1 (CASZ1) is a protein with two splicing variants, CASZ1a and CASZ1b.
  • CASZ1 participates in vital physiological processes including tissue differentiation and aldosterone antagonism.
  • Genetic and epigenetic alterations in CASZ1 are implicated in cardiovascular disorders like congenital heart diseases, chronic venous diseases, and hypertension.

Purpose of the Study:

  • To review the physiological functions of CASZ1.
  • To explore the association between CASZ1 aberrations and the pathogenesis of cardiovascular diseases.
  • To investigate the role of CASZ1 in cancer development, highlighting its potential "double-agent" function.

Main Methods:

  • Literature review of existing studies on CASZ1.
  • Analysis of genetic and epigenetic alterations of CASZ1 in disease contexts.
  • Synthesis of findings regarding CASZ1's role in physiological and pathological processes.

Main Results:

  • CASZ1 is involved in fundamental biological processes.
  • CASZ1 alterations are linked to various cardiovascular conditions.
  • CASZ1 exhibits a complex, potentially dual role in cancer progression.

Conclusions:

  • CASZ1 is a significant factor in cardiovascular disease pathogenesis.
  • CASZ1's multifaceted role in cancer warrants further investigation.
  • Understanding CASZ1's mechanisms is crucial for therapeutic strategies in cardiovascular diseases and cancer.
Keywords:
CASZ1cancercardiovascular disorderscell differentiation

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