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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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SARS-CoV-2 Related Myocarditis: What We Know So Far

Raffaella Mistrulli1, Armando Ferrera1, Melwyn Luis Muthukkattil1

  • 1Clinical and Molecular Medicine Department, Sapienza University of Rome, 00185 Roma, Italy.

Journal of Clinical Medicine
|July 29, 2023
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (COVID-19) can cause myocarditis, a heart inflammation. This review covers COVID-19 myocarditis, its management, and vaccine-associated myocarditis.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (COVID-19) can lead to cardiovascular complications.
  • Myocarditis, or heart inflammation, is a rare but serious complication of COVID-19.

Purpose of the Study:

  • To review current data on COVID-19-related myocarditis.
  • To discuss management strategies and therapies for COVID-19 myocarditis.
  • To briefly describe COVID-19 vaccine-associated myocarditis.

Main Methods:

  • Literature review of current data on COVID-19 myocarditis.
  • Analysis of management strategies and therapeutic approaches.
  • Inclusion of information on vaccine-associated myocarditis.

Main Results:

  • COVID-19 myocarditis affects a minority of patients, with a prevalence of 10-105 cases per 100,000 infected individuals.
  • Fulminant myocarditis (FM) presents with cardiogenic shock and ventricular arrhythmias, leading to high mortality.
  • Standard medical therapy may be insufficient, requiring inotropic and immunosuppressive drugs like corticosteroids.

Conclusions:

  • COVID-19 myocarditis requires specific clinical attention due to its potential severity.
  • Management may necessitate advanced therapies beyond standard ACE inhibitors and beta-blockers.
  • Understanding vaccine-associated myocarditis is crucial for clinicians.

Keywords:
COVID-19COVID-19 and myocarditisCOVID-19 related myocarditisCOVID-19–associated acute myocarditisSARS-CoV-2acute myocarditiscardiovascular sequelae of COVID-19post-acute sequelae of SARS-CoV-2

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