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Principles of Rational COVID-19 Therapy in Pediatrics
Oksana D Nemyatykh1, Marina A Maistrenko2, Dina D Demchenko1
1Department of Management and Economics of Pharmacy, Faculty of Pharmacy, Saint-Petersburg State Chemical Pharmaceutical University, Ministry of Health of Russia, Prof. Popova Str., 14 Lit. A, 197376 Saint-Petersburg, Russia.
Journal of Clinical Medicine
|July 29, 2023
Summary
Global COVID-19 pediatric therapy primarily uses an etiotropic-pathogenetic approach. Key drugs include remdesivir, nirmatrelvir/ritonavir, dexamethasone, and tocilizumab, with ongoing research into long-term effects.
Area of Science:
- Pediatric Infectious Diseases
- Pharmacotherapy
- Global Health
Background:
- COVID-19 presents unique challenges in pediatric populations.
- Understanding global therapeutic strategies is crucial for effective patient management.
Purpose of the Study:
- To comparatively assess COVID-19 therapy concepts for pediatric patients globally.
- To analyze current etiotropic, pathogenetic, and symptomatic treatment approaches.
Main Methods:
- Structural analysis of drugs and treatment strategies.
- Review of international clinical practice guidelines and drug utilization.
Main Results:
- An etiotropic-pathogenetic approach dominates global pediatric COVID-19 treatment.
- Eight etiotropic and 18 pathogenetic therapy agents are used internationally.
- Remdesivir, nirmatrelvir/ritonavir, dexamethasone, and tocilizumab are frequently used.
Conclusions:
- The current global approach to pediatric COVID-19 therapy prioritizes etiotropic and pathogenetic treatments.
- Further research is needed to evaluate treatment regimens and long-term consequences of childhood COVID-19.
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