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Updated: Jul 21, 2025

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
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Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization

Christopher A Lucchesi1,2, Demitria M Vasilatis1,3, Saisamkalpa Mantrala1

  • 1VA Northern California Health Care System, Mather, CA 95655, USA.

International Journal of Molecular Sciences
|July 29, 2023
PubMed

Insights

Pesticide exposure is linked to increased bladder cancer risk. This review details pathways like MMP-2, TGF-β, and STAT3 involved in cancer development and resistance to treatment.

Area of Science:

  • Environmental Health
  • Oncology
  • Toxicology

Background:

  • Bladder cancer has multiple risk factors.
  • Pesticide exposure is a suspected risk factor, with recent reports showing a strong correlation.
  • The precise mechanisms linking pesticides to bladder cancer are not fully understood.

Purpose of the Study:

  • To review current knowledge on pesticide exposure and its association with bladder cancer.
  • To explore the pathways through which pesticides may influence bladder cancer initiation, progression, and chemoresistance.

Main Methods:

  • This study is a narrative review of existing literature.
  • It synthesizes information on pesticide exposure and bladder cancer.
  • Key molecular pathways (MMP-2, TGF-β, STAT3) and cellular processes (drug efflux, DNA repair, apoptosis resistance) are discussed.

Main Results:

  • Pesticide exposure is associated with increased bladder cancer risk in humans and dogs.
  • Specific pesticides modulate pathways crucial for oncogenesis and metastasis.
  • Pesticide exposure can induce resistance to chemotherapy through mechanisms like altered drug efflux, DNA repair, and apoptosis resistance.

Conclusions:

  • Pesticide exposure presents a significant risk factor for bladder cancer.
  • Understanding the molecular mechanisms can inform therapeutic strategies.
  • Targeting pathways like MMP-2, TGF-β, STAT3, and resistance mechanisms may offer new treatment avenues.
Keywords:
bladder cancermetastasispesticide exposure

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