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Potential Therapeutic Target and Vaccines for SARS-CoV-2.
Mohamed A Hussain1, Mohamed M Hassan2, Bashir Abdrhman Bashir3
1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, International University of Africa, Khartoum 11111, Sudan.
Pathogens (Basel, Switzerland)
|July 29, 2023
Summary
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is most similar to SARS-CoV. The ORF8 protein is a potential therapeutic target, and SARS-CoV-2 proteins may serve as vaccine sources.
Area of Science:
- Virology
- Genomics
- Bioinformatics
Background:
- The emergence of SARS-CoV-2 has spurred significant scientific interest in coronaviruses.
- Understanding SARS-CoV-2's genomic behavior aids in developing countermeasures.
Purpose of the Study:
- To conduct a comparative genomic analysis of SARS-CoV-2 against other human coronaviruses.
- To identify potential therapeutic targets and vaccine candidates based on genomic similarities and differences.
Main Methods:
- Retrieval of human coronavirus genomes from NCBI.
- Comparative genomic analysis utilizing various bioinformatics tools.
Main Results:
- SARS-CoV-2 exhibits the highest genomic similarity to SARS-CoV.
- The ORF8 gene, present in SARS-CoV-2 but not SARS-CoV, is identified as a potential therapeutic target due to its predicted transmembrane function.
- Proteins ORF1ab, ORF1a, ORF8, and S are identified as potentially immunogenic and suitable for vaccine development.
Conclusions:
- SARS-CoV-2 shares significant genomic features with SARS-CoV.
- The ORF8 protein presents a promising target for inhibiting viral transmission.
- Specific SARS-CoV-2 proteins offer potential as sources for vaccine development.
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